rehab centers,Leptin Works in Many Brain Areas

A handful of individuals have a rare genetic mutation that causes
them to make no leptin at all.  These individuals become morbidly obese
because they never get a proper full signal.  By comparison, 99.99% of
overweight people make too much leptin; however, the leptin does not
get into the brain properly (leptin resistance), so they basically behave
like the person who makes no leptin at all.

When researchers give leptin to the rare person who makes none, the
person quits eating all the time, gets a proper full signal, and loses
weight.  When researchers give leptin to the other 99.99% of
individuals, it simply makes blood levels of leptin rise even higher
and leptin resistance worsens.  Researchers are trying to make nasal
sprays that enter the brain directly, which has some possibility of
working.  However, it is far easier to simply eat in harmony with the
hormone as explained by The Leptin Diet, which reduces leptin
resistance, allowing leptin to enter the brain in the natural way and
provide a normal full signal.  Individuals are often amazed at how
following the Five Rules of The Leptin Diet stops their obsession and
craving for food.

Fascinating new research
on rare people who make no leptin at all is showing that leptin has a
profound influence on numerous regions in the brain.  It is already
well known that leptin communicates directly to the hypothalamus gland, thus
controlling the subconscious core of appetite and energy-producing
brain circuitry.  What is new about this study is that leptin is shown
to activate numerous other areas in the brain, including the cerebral
cortex executive centers of the brain that are involved with rational
self control. 

In fact, leptin actually caused the cerebral cortex to grow, literally
strengthening the structure and function of this area of the brain. 
This is a dramatic discovery.  It means that leptin resistant
overweight children are at risk of poor brain development and leptin
resistant adults are at risk of accelerated brain aging based in part
on atrophy of the cerebral cortex.  The cerebral cortex is vital for
many cognitive tasks in addition to issues of food acquisition and
appetite control.  In fact, this problem cuts to the core of any
addictive tendency in any subject relating to a lack of self control.

The researchers also found that the cerebellum was activated by
leptin.  The cerebellum is involved with the coordination of physical
motion.  A weak cerebellum contributes to problems such as anxiety and
learning disabilities such as dyslexia. 

It is well known that leptin acts as a primary antioxidant in the
brain, a main way in which the brain buffers the stress of
excitotoxins.  Excitotoxins are a primary cause of brain stress, developmental brain issues, and age-related decline.  A
combination of leptin deficiency in the brain and excitotoxin excess is
linked to ADHD, Down syndrome, and Autism spectrum disorders, as well
as age-related cognitive decline, Alzheimer’s and Parkinson’s disease. 
Common dietary excitotoxins include MSG, food coloring, aspartame, and
flavoring systems used by fast food restaurants and packaged food
producers to addict consumers to their brand.  Immunizations prime
brain cells to become hyper-responsive and thereby magnify excitotoxic
stress.

While there is much we do not know this new research demonstrates that
proper leptin levels within the brain are vital for intelligence and
the ability to make and follow through on healthy choices in one’s
life.